p-Toluenesulfonic acid → Methyl 2-(2-formylphenyl)acetate

HRID 373953ノート

反応式

HRID 373953 の反応式
[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11])=[O:2].[C:13]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[CH:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([O:12][CH3:13])=[O:11])=[O:2]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 5289058Ortho-formylphenylacetic acid

生成物 1

HCID 12241427Methyl 2-(2-formylphenyl)acetate収率 18,652%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

24.0 g (0.15 mole) of 2-formylphenylacetic acid and 0.1 g of p-toluenesulfonic acid in 250 ml of methanol are refluxed for 2 hours. Thereafter, the solution is evaporated down, the residue is taken up in diethyl ether and the solution is washed with dilute HCl. The organic phase is separated off, dried over MgSO4 and evaporated down. The residue is purified by distillation (90° C., 0.4 mbar). 19.3 g (74%) of methyl 2-formylphenylacetate are obtained as a colorless liquid in this manner.

後処理

  1. customThereafter, the solution is evaporated down
  2. washthe solution is washed with dilute HCl
  3. customThe organic phase is separated off
  4. dry with materialdried over MgSO4
  5. customevaporated down
  6. distillationThe residue is purified by distillation (90° C., 0.4 mbar)

出典と根拠

ORDレコード
ord-618564f453c34b6b837166faab5ae121
出典データセット
uspto-grants-1992_11
特許番号
US05166216

反応ノート

読み込み中…