化工社化工社 化学情報印刷レポート · 研究参考用
Ammonium fluoride → 3'-Fluorothymidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonium fluoride | HCID 25516 | — |
| 反応物 | 2,3'-Anhydrothymidine | HCID 6915752 | — |
| 反応物 | Potassium fluoride, 99%, spray-dried | HCID 53443437 | — |
| 反応物 | 3'-Mesylthymidine | HCID 53914209 | — |
| 溶媒 | Ethylene Glycol | HCID 174 | — |
| 生成物 | 3'-Fluorothymidine | HCID 33039 | 10% |
反応手順
3'-Mesylthymidine or 2,3'-anhydrothymidine is allowed to react with potassium hydrogen fluoride or ammonium fluoride in ethylene glycol at 191° C. for 10 to 90 minutes, thus giving 3'-deoxy-3'-fluorothymidine (yield: 10 to 14%) [Japanese Patent Publication No. 10472 (1973)].
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05166327 |
| 出典データセット | uspto-grants-1992_11 |
| ORD ID | ord-1691f48da1a64b31970d925a16ff228d |
| 出典メモ | uspto-grants-1992_11 |