HRID374078

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID25516

Ammonium fluoride

H4FN

结构：Cc1cn2c(nc1=O)O[C@H]1C[C@H]2O[C@@H]1CO

HCID6915752

未命名化合物

HCID53443437

未命名化合物

结构：Cc1cn([C@H]2C[C@@](O)(S(C)(=O)=O)[C@@H](CO)O2)c(=O)[nH]c1=O

HCID53914209

未命名化合物

PRODUCTS

生成物

结构：Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O

HCID33039

Alovudine

C10H13FN2O4

收率 10%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID174

Ethylene glycol

C2H6O2

PROCEDURE

实验过程

3'-Mesylthymidine or 2,3'-anhydrothymidine is allowed to react with potassium hydrogen fluoride or ammonium fluoride in ethylene glycol at 191° C. for 10 to 90 minutes, thus giving 3'-deoxy-3'-fluorothymidine (yield: 10 to 14%) [Japanese Patent Publication No. 10472 (1973)].