2-Mercaptobenzoic Acid → 2-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid

HRID 3742

反応式

HRID 3742 の反応式
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1.[C:21]([OH:30])(=[O:29])[C:22]1[C:23](=[CH:25][CH:26]=[CH:27][CH:28]=1)[SH:24]>CO.O1CCCC1>[S:17]([C:14]1[CH:15]=[CH:16][C:11]([NH:3][C:2]([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][S:24][C:23]2[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=2[C:21]([OH:30])=[O:29])=[O:1])=[CH:12][CH:13]=1)(=[O:19])(=[O:18])[NH2:20]

参加物

5

反応物 2

HCID 54432-Mercaptobenzoic AcidHCID 4629384-(3-Oxo-1,2-benzothiazol-2-yl)benzenesulfonamide

生成物 1

HCID 107663952-[2-(4-Sulfamoylphenylcarbamoyl)phenyldisulfanyl]benzoic acid収率 95.5%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl)benzene sulfonamide in a mixture of 15 mL of methanol and 15 mL of tetrahydrofuran, and 0.23 g (1.5 mmol) of thiosalicylic acid. The product was washed with ether and dried in vacuo to give 0.66 g of the title compound, mp 276°-278° C.

後処理

  1. customThis compound was prepared
  2. washThe product was washed with ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-40ccfc0f214f4effb36ca78515638c20
出典データセット
uspto-grants-1998_03
特許番号
US05734081

関連ノート

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