関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-Fluoroethyl bromide | HCID 12982 | — |
| 反応物 | 2-Mercaptophenylsulfonamide triethylamine salt | HCID 19809753 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-(2-Fluoroethylthio)-phenylsulfonamide | HCID 19809754 | 571.9% |
反応手順
A mixture of 29 g of the 2-mercaptophenylsulfonamide triethylamine salt obtained in accordance with Example H6 and 2 g of 2-bromo-1-fluoroethane in 130 ml of tetrahydrofuran is stirred for 6 hours at a temperature of +40° C. to +45° C. The reaction mixture is then cooled to 0° C. and filtered. The filtrate is evaporated and the resulting residue is crystallized from methylene dichloride to give 21.2 g (90.2% of theory) of 2-(2-fluoroethylthio)-phenylsulfonamide having a melting point of +84° to +85° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05166430 |
|---|
| 出典データセット | uspto-grants-1992_11 |
|---|
| ORD ID | ord-1fb3128e46c04bed8f76a416cf3704e2 |
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| 出典メモ | uspto-grants-1992_11 |
|---|
