Thioglycerol → 2-(2,3-Dihydroxypropyldisulfanyl)-N-(4-sulfamoylphenyl) benzamide

HRID 3744

反応式

HRID 3744 の反応式
[O:1]=[C:2]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[S:4][N:3]1[C:11]1[CH:16]=[CH:15][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[CH:13][CH:12]=1.O1CCCC1.[OH:26][CH:27]([CH2:30][OH:31])[CH2:28][SH:29]>CO>[OH:26][CH:27]([CH2:30][OH:31])[CH2:28][S:29][S:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:2]([NH:3][C:11]1[CH:16]=[CH:15][C:14]([S:17](=[O:19])(=[O:18])[NH2:20])=[CH:13][CH:12]=1)=[O:1]

参加物

5

反応物 3

HCID 7291ThioglycerolHCID 8028TetrahydrofuranHCID 4629384-(3-Oxo-1,2-benzothiazol-2-yl)benzenesulfonamide

生成物 1

HCID 108356092-(2,3-Dihydroxypropyldisulfanyl)-N-(4-sulfamoylphenyl) benzamide

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared according to the method of Example 132 using a suspension of 0.46 g (1.5 mmol) of 4-(3-oxo-3H-benzo[d]isothiazol-2-yl) benzenesulfonamide in a mixture of 15 mL of methanol, and 15 mL of tetrahydrofuran and 2,3-dihydroxy-1-propanethiol. The product was washed with ether and dried in vacuo to give 0.61 g of the title compound, mp>260° C.

後処理

  1. customThis compound was prepared
  2. washThe product was washed with ether
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-039c45d2d6ad447186631f36b49d7ebe
出典データセット
uspto-grants-1998_03
特許番号
US05734081

関連ノート

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