DL-Arabinose → Pentosidine

HRID 374409

反応式

HRID 374409 の反応式
[CH2:1](O)[CH:2](O)[CH:3](O)[CH:4](O)[CH:5]=O.[NH2:11][C@H:12]([C:18]([OH:20])=[O:19])[CH2:13][CH2:14][CH2:15][CH2:16][NH2:17].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27](=[NH:29])[NH2:28].O=C[C@@H]([C@@H]([C@@H](CO)O)O)O>>[CH:2]1[CH:3]=[C:4]2[C:5](=[N:29][C:27]([NH:26][CH2:25][CH2:24][CH2:23][C@H:22]([NH2:21])[C:30]([OH:32])=[O:31])=[N:28]2)[N:17]([CH2:16][CH2:15][CH2:14][CH2:13][C@H:12]([NH2:11])[C:18]([OH:20])=[O:19])[CH:1]=1

参加物

5

反応物 4

HCID 854DL-ArabinoseHCID 5962L-LysineHCID 5311110Aldehydo-D-riboseHCID 178418600HCID 178418600、化合物

生成物 1

HCID 119593Pentosidine

反応条件

温度
80 °C

実験手順

In order to confirm the pentose-derived nature of the native fluorophore 100 mM each of L-lysine, L-arginine and D-ribose were heated for 1 hour at 80° C. Injection of a small amount of this synthetic material on HPLC revealed a major fluorescent peak coeluting with the native fluorophore. (see FIG. 5) In order to substantiate the proposed structure, the synthetic fluorophore was prepared preparatively and purified. Total yield was 21 mg; i.e., 0.02% of the reactants.

後処理

  1. customthe synthetic fluorophore was prepared preparatively
  2. custompurified

出典と根拠

ORDレコード
ord-8357ab42bf30496287c2be5cf03b34d8
出典データセット
uspto-grants-1996_01
特許番号
US05480807

関連ノート

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