Methanesulfonic Acid → 1-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

HRID 374429ノート

反応式

HRID 374429 の反応式
C[S:2]([OH:5])(=[O:4])=[O:3].[OH-].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]>O1CCCC1>[S:2]([O-:5])([O-:15])(=[O:4])=[O:3].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20].[CH3:7][N+:8]1[CH:13]=[C:12]([C:14]([O:16][CH3:17])=[O:15])[CH:11]=[N:10][C:9]=1[NH:18][CH:19]([CH3:21])[CH3:20]

参加物

4

反応物 2

HCID 6395Methanesulfonic AcidHCID 196988161-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide

生成物 1

HCID 676602951-Methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium sulfate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

1.09 mlg [sic] (16.78 mol; 1.61 g) of methanesulfonic acid is added to a solution of 1-methyl-2-isopropylamino-5-methoxycarbonylpyrimidinium hydroxide (3.48 g; 15.35 mol) dissolved in 100 ml of anhydrous tetrahydrofuran. The mixture is stirred under argon at room temperature for one hour. The precipitate which forms is filtered and then rinsed with ether.

後処理

  1. filtrationThe precipitate which forms is filtered
  2. washrinsed with ether

出典と根拠

ORDレコード
ord-c030ad34ab36425c8415fa7c69c341ec
出典データセット
uspto-grants-1996_01
特許番号
US05480884

反応ノート

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