Bromine → 2-(Bromoacetyl)-5-chlorothiophene
反応式
[Br:1]Br.[C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)(=[O:5])[CH3:4].CCOCC.CCCCCC>C(Cl)(Cl)Cl.O>[Br:1][CH2:4][C:3]([C:6]1[S:7][C:8]([Cl:11])=[CH:9][CH:10]=1)=[O:5]参加物
6
実験手順
A solution of bromine (18.90 g, 118 mmol) in chloroform is added to a solution of 2-acetyl-5-chlorothiophene (19.00 g, 118 mmol) in chloroform at 40°-45° C. The reaction mixture is stirred at room temperature for two hours and diluted with water. The organic layer is separated, dried over MgSO4 and concentrated in vacuo to give a solid. The solid is slurried in an ether/hexane solution, filtered and dried to give the title product as a solid (12.20 g, mp 68°-70° C.).
後処理
- customThe organic layer is separated
- dry with materialdried over MgSO4
- concentrationconcentrated in vacuo
- customto give a solid
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-c3a9920f6fd74ed38401012bf093bc09
- 出典データセット
- uspto-grants-1996_01
- 特許番号
- US05480902
反応ノート
読み込み中…