Hydrochloric Acid → (4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride

HRID 374554ノート

反応式

HRID 374554 の反応式
C([N:8]1[C@@H:16]2[C@@H:12]([CH2:13][NH:14][CH2:15]2)[O:11][CH2:10][CH2:9]1)C1C=CC=CC=1.[ClH:17]>C(O)C.[Pd]>[ClH:17].[ClH:17].[C@@H:12]12[CH2:13][NH:14][CH2:15][C@@H:16]1[NH:8][CH2:9][CH2:10][O:11]2

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 10856960rac-(4aR,7aS)-4-benzyl-octahydropyrrolo[3,4-b]morpholine

生成物 1

HCID 22857293(4aS,7aR)-rel-Octahydropyrrolo[3,4-b][1,4]oxazine dihydrochloride

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

26 g (0.11 mol, 92% strength) of cis-5-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are hydrogenated on 3 g of palladium/active charcoal (10% Pd) at 100° C. and 100 bar H2 in 180 ml of ethanol and 19 ml of concentrated hydrochloric acid. The catalyst is filtered off with suction, the filtrate is concentrated and the crystals which have separated out are dried in a desiccator over phosphorus pentoxide.

後処理

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. customthe crystals which have separated out
  4. dry with materialare dried in a desiccator over phosphorus pentoxide

出典と根拠

ORDレコード
ord-ccf30365f6c34b6d8d579e5f4381522a
出典データセット
uspto-grants-1996_01
特許番号
US05480879

反応ノート

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