Water → HCID 23368712、化合物

HRID 374634ノート

反応式

HRID 374634 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:17][S:18]([C:21]2[CH:27]=[CH:26][C:24]([CH3:25])=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8].[H-].[Na+].[CH3:30]C(C)(Br)C(N)=O.O.[CH3:38][N:39]([CH:41]=[O:42])[CH3:40]>>[S:18]([N:17]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:16][C:6]=1[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[Cl:15])=[O:8])[CH2:30][C:41](=[O:42])[N:39]([CH3:40])[CH3:38])([C:21]1[CH:22]=[CH:23][C:24]([CH3:25])=[CH:26][CH:27]=1)(=[O:19])=[O:20]

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 1012352-Bromo-2-methylpropanamideHCID 23368680N-[4-Chloro-2-(2-chlorobenzoyl)phenyl]-4-methylbenzene-1-sulfonamide

生成物 1

HCID 23368712HCID 23368712、化合物

実験手順

8.4 g of 5,2'-dichloro-2-tosylaminobenzophenone are dissolved in 40 ml of DMF and treated with 0.7 g of 80% sodium hydride; after 15 minutes, 10 g of dimethylbromoacetamide, prepared in Example 1, are added and the mixture is stirred overnight at RT. The reaction medium is poured into water, the precipitate formed is filtered off and taken up with DCM and the solution is dried and concentrated. 9.2 g of the expected product are obtained after crystallization from isopropyl ether.

後処理

  1. additionare added
  2. customthe precipitate formed
  3. filtrationis filtered off
  4. customthe solution is dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-accba46b8609424fab5c189690a3d9a3
出典データセット
uspto-grants-1996_01
特許番号
US05481005

反応ノート

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