HCID 20788751、化合物 → HCID 20788749、化合物
反応式
C([O:5][C:6](=[O:27])[C@H:7]([CH3:26])[NH:8][C:9](=[O:25])[CH:10]([O:14][C:15]1[N:20]=[C:19]([O:21][CH3:22])[CH:18]=[C:17]([O:23][CH3:24])[N:16]=1)[CH:11]([CH3:13])[CH3:12])(C)(C)C>FC(F)(F)C(O)=O>[CH3:22][O:21][C:19]1[CH:18]=[C:17]([O:23][CH3:24])[N:16]=[C:15]([O:14][CH:10]([CH:11]([CH3:13])[CH3:12])[C:9]([NH:8][C@H:7]([C:6]([OH:27])=[O:5])[CH3:26])=[O:25])[N:20]=1参加物
3
実験手順
2 g of N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine tert-butyl ester (Example 1.023) are added to 20 ml of trifluoroacetic acid. After one hour, the reaction mixture is concentrated by evaporation, taken up in ethyl acetate, washed once with dilute hydrochloric acid, dried over sodium sulfate and again concentrated by evaporation, yielding N-[2-[(4,6-dimethoxy-pyrimidin-2-yl)oxy]-3-methyl-butyryl]-L-alanine as a crystalline product; m.p.: 157°-160° C. (from ethyl acetate).
後処理
- concentrationthe reaction mixture is concentrated by evaporation
- washwashed once with dilute hydrochloric acid
- dry with material