Hydroxyphenylacetic acid → 2,6-Dimethylcyclohexyl 4-hydroxyphenylacetate

HRID 374832

反応式

HRID 374832 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[CH:3]1[OH:9].[OH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18](O)=[O:19])=[CH:13][CH:12]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1C=CC=CC=1>O>[OH:10][C:11]1[CH:16]=[CH:15][C:14]([CH2:17][C:18]([O:9][CH:3]2[CH:4]([CH3:8])[CH2:5][CH2:6][CH2:7][CH:2]2[CH3:1])=[O:19])=[CH:13][CH:12]=1

参加物

6

反応物 4

HCID 127Hydroxyphenylacetic acidHCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 214282,6-Dimethylcyclohexanol

生成物 1

HCID 541091042,6-Dimethylcyclohexyl 4-hydroxyphenylacetate収率 51%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2,6-dimethylcyclohexyl alcohol (11.4 g), 4-hydroxyphenylacetic acid (9.12 g), p-toluenesulfonic acid (1 g) and benzene (300 mL) was refluxed with continuous water separation for 20 hours. The mixture was filtered and the filtrate was washed with a 10% Na2CO3 solution, then with water. Drying over MgSO4 and evaporation in vacuo afforded 8.02 g of 2,6-dimethylcyclohexyl 4-hydroxyphenylacetate. That product has the structural formula: ##STR26##

後処理

  1. filtrationThe mixture was filtered
  2. washthe filtrate was washed with a 10% Na2CO3 solution
  3. dry with materialDrying over MgSO4 and evaporation in vacuo

出典と根拠

ORDレコード
ord-2c76f13321f34205bf38e49ccfc694fa
出典データセット
uspto-grants-1996_01
特許番号
US05482961

関連ノート

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