Ammonia → 2-Amino-5-chloro-3-nitrobenzotrifluoride

HRID 374856ノート

反応式

HRID 374856 の反応式
[N+:1]([C:4]1[C:5](Cl)=[C:6]([C:11]([F:14])([F:13])[F:12])[CH:7]=[C:8]([Cl:10])[CH:9]=1)([O-:3])=[O:2].[NH3:16]>[Cl-].C([N+](CC)(CC)CC)C.O>[NH2:16][C:5]1[C:4]([N+:1]([O-:3])=[O:2])=[CH:9][C:8]([Cl:10])=[CH:7][C:6]=1[C:11]([F:14])([F:13])[F:12]

参加物

5

反応物 2

HCID 222AmmoniaHCID 136718542,5-Dichloro-1-nitro-3-(trifluoromethyl)benzene

生成物 1

HCID 27376442-Amino-5-chloro-3-nitrobenzotrifluoride

試薬・触媒・溶媒 2

HCID 5946Tetraethylammonium Chloride触媒HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

260 g of 3-nitro-2,5-dichlorobenzotrifluoride, 130 ml of water and 10 g of tetraethylammonium chloride were initially introduced into an autoclave and 120 ml of liquid ammonia were forced in. The mixture was then heated to 130° C. and stirred at this temperature for 10 hours. After cooling, the mixture was filtered, and the precipitate which had been separated off was washed with water and dried. 194 g of 2-amino-3-nitro-5-chlorobenzotrifluoride with a melting point of 67° C. were obtained.

後処理

  1. temperatureAfter cooling
  2. filtrationthe mixture was filtered
  3. customthe precipitate which had been separated off
  4. washwas washed with water
  5. customdried

出典と根拠

ORDレコード
ord-5d2dae1bfb344960ad7a66668fbc06d7
出典データセット
uspto-grants-1996_01
特許番号
US05482956

反応ノート

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