2-Ethylhexanal → 5-Amino-5-hydroxymethyl-2-(3-heptyl)-1,3-dioxane

反応式

[CH2:1]([CH:3]([CH2:6][CH2:7][CH2:8][CH3:9])[CH:4]=[O:5])[CH3:2].[OH:10][CH2:11][C:12]([N+:17]([O-])=O)([CH2:15]O)[CH2:13][OH:14]>>[NH2:17][C:12]1([CH2:13][OH:14])[CH2:11][O:10][CH:4]([CH:3]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:1][CH3:2])[O:5][CH2:15]1

参加物

反応物 2

HCID 312412-Ethylhexanal

HCID 31337Tris(hydroxymethyl)nitromethane

生成物 1

HCID 189960495-Amino-5-hydroxymethyl-2-(3-heptyl)-1,3-dioxane収率 95.1%

実験手順

Procedure of Example 2 was repeated with 6.41 g of 2-ethylhexanal and 7.56 g of 2-(hydroxymethyl)-2-nitro-1,3-propanediol to give 11 g of 5-nitro-5-hydroxymethyl-1,3-dioxane derivative, which was reduced and distilled at 175°-178° C. to give 8.7 g of the product.

出典と根拠

ORDレコード: ord-3a82a3418c454d79b570a00b1fb4f332
出典データセット: uspto-grants-1996_01
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05482965

反応ノート

読み込み中…