2-Methyl-2-nitro-1,3-propanediol → 5-Methyl-5-nitro-1,3-dioxan-2-one

HRID 374865

反応式

HRID 374865 の反応式
[CH3:1][C:2]([N+:7]([O-:9])=[O:8])([CH2:5][OH:6])[CH2:3][OH:4].[C:10]1(=O)OCC[O:11]1>C(OCC)(=O)C>[CH3:1][C:2]1([N+:7]([O-:9])=[O:8])[CH2:5][O:6][C:10](=[O:11])[O:4][CH2:3]1

参加物

4

反応物 2

HCID 64802-Methyl-2-nitro-1,3-propanediolHCID 7303Ethylene carbonate

生成物 1

HCID 189960545-Methyl-5-nitro-1,3-dioxan-2-one

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 2-methyl-2-nitro-1,3-propanediol and ethylene carbonate is heated overnight. The reaction mixture is diluted with ethyl acetate and the solution is washed with water. The organic phase is dried and concentrated to obtain 5-methyl-5-nitro-1,3-dioxan-2-one. This is dissolved in methanol and hydrogenated under pressure to give the 5amino compound which is acylated with dodecanoyl chloride to give the product.

後処理

  1. washthe solution is washed with water
  2. customThe organic phase is dried
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-95f89e8157fe4d36923e6412f8b53d05
出典データセット
uspto-grants-1996_01
特許番号
US05482965

関連ノート

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