Potassium Carbonate → 5-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)-2,2-diacetyl-1,3-benzodioxole

HRID 374887ノート

反応式

HRID 374887 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12]C(=O)[N:10]([CH:14]([CH3:24])[CH2:15][C:16]3[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([OH:23])[CH:17]=3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Br[C:26](Br)([C:30](=[O:32])[CH3:31])[C:27](=[O:29])[CH3:28].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]([OH:12])[CH2:9][NH:10][CH:14]([CH3:24])[CH2:15][C:16]2[CH:21]=[CH:20][C:19]3[O:22][C:26]([C:30](=[O:32])[CH3:31])([C:27](=[O:29])[CH3:28])[O:23][C:18]=3[CH:17]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 131689003,3-Dibromopentane-2,4-dioneHCID 156692045-(3-Chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolidinone

生成物 1

HCID 158132125-(2-((2-(3-Chlorophenyl)-2-hydroxyethyl)amino)propyl)-2,2-diacetyl-1,3-benzodioxole

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

One equivalent of 5-(3-chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolidinone, prepared by the procedure of U.S. Pat. No. 5,061,727, Example 1, is combined with 1.1 equivalents of 3,3-dibromo-2,4-pentanedione and 2.2 equivalents of powdered potassium carbonate in acetonitrile. The reaction mixture is stirred at room temperature for 48 hours, evaporated in vacuo and partitioned between methylene chloride and water. The organic layer is dried, filtered and evaporated in vacuo to give 5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)amino)propyl)-2,2-diacetyl-1,3-benzodioxole.

後処理

  1. customevaporated in vacuo
  2. custompartitioned between methylene chloride and water
  3. customThe organic layer is dried
  4. filtrationfiltered
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-9c0e2da1bd314aebb80bdb61f0cabafb
出典データセット
uspto-grants-1996_01
特許番号
US05482971

反応ノート

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