Hydrochloric Acid → HCID 131719242、化合物

HRID 374894

反応式

HRID 374894 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:14]([CH3:28])[CH2:15]C3CCC4OCC(=O)CC=4OC3)[CH2:9]2)[CH:5]=[CH:6][CH:7]=1.[BH4-].[Na+].[OH2:31].Cl.[CH3:33][OH:34]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]2[O:12][C:11](=[O:13])[N:10]([CH:14]([CH3:28])[CH2:15][CH:9]3[O:34][C:33]4[CH2:5][CH2:6][CH2:7][CH2:2][O:31][C:3]=4[CH:4]=[C:8]3[OH:12])[CH2:9]2)[CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 887MethanolHCID 962WaterHCID 4311764Sodium borohydrideHCID 189963407-(2-(5-(3-Chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,5-dioxabenzocycloheptan-3-one

生成物 1

HCID 131719242HCID 131719242、化合物

実験手順

One equivalent of 5-(3-chlorophenyl)-3-(2-(3,4-dihydroxyphenyl)-1-methylethyl)-2-oxazolidinone, prepared by the procedure of U.S. Pat. No. 5,061,727 Example 1, is treated with one equivalent of 1,3-dibromoacetone and excess potassium carbonate in acetonitrile. The mixture is stirred at room temperature for 18 hours, filtered and evaporated in vacuo to give 7-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl)-1,5-dioxabenzocycloheptan-3-one. One equivalent of this ketone is reduced, at room temperature for one hour, with excess sodium borohydride in methyl alcohol. The reaction mixture is poured into water, made acidic with 1N hydrochloric acid and extracted with methylene chloride. The organic extracts are dried and evaporated in vacuo to give 7-(2-(5-(3-chlorophenyl)-2-oxo-3-oxazolidinyl)propyl-1,5-dioxabenzocycloheptan-3-ol. Hydrolysis with 2.5N sodium hydroxide gives the title compound.

後処理

  1. extractionextracted with methylene chloride
  2. customThe organic extracts are dried
  3. customevaporated in vacuo

出典と根拠

ORDレコード
ord-12b1efd400d64ec79bd3db4ca9efa5c8
出典データセット
uspto-grants-1996_01
特許番号
US05482971

関連ノート

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