Methanol → N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylthio-4-phenyl-3-quinolinecarboxamide

HRID 374995ノート

反応式

HRID 374995 の反応式
[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:11](Cl)=[N:12][C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:9].CO.C(S)[CH2:40][S:41]([O-])(=O)=O.[Na+]>C1COCC1.O>[F:1][C:2]([F:36])([F:35])[C:3]1[CH:4]=[C:5]([CH:28]=[C:29]([C:31]([F:34])([F:33])[F:32])[CH:30]=1)[CH2:6][N:7]([CH3:27])[C:8]([C:10]1[C:11]([S:41][CH3:40])=[N:12][C:13]2[C:18]([C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:9]

参加物

6

反応物 3

HCID 887MethanolHCID 21463112N-[3,5-Bis(trifluoromethyl)benzyl]-2-chloro-N-methyl-4-phenyl-3-quinolinecarboxamideHCID 23662354Mesna

生成物 1

HCID 21463181N-[3,5-Bis(trifluoromethyl)benzyl]-N-methyl-2-methylthio-4-phenyl-3-quinolinecarboxamide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of the compound obtained in Example 269 (100 mg) in THF (6 ml)-methanol (2 ml) was added 15% MeSNa in water (4 ml), and the mixture was stirred for 8 hours with heating under reflux. The solvent was evaporated and the residue was dissolved in ethyl acetate. The solution was washed with water, dried and evaporated to yield the title compound as colorless crystals (55 mg).

後処理

  1. temperaturewith heating
  2. temperatureunder reflux
  3. customThe solvent was evaporated
  4. dissolutionthe residue was dissolved in ethyl acetate
  5. washThe solution was washed with water
  6. customdried
  7. customevaporated

出典と根拠

ORDレコード
ord-7529599c4d144de69a3dc42e3c245890
出典データセット
uspto-grants-1996_01
特許番号
US05482967

反応ノート

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