Ethylamine → N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

HRID 375113

反応式

HRID 375113 の反応式
[N+:1]([C:4]1[N:5]=[CH:6][N:7]([CH:9]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:10]([O:12]CC)=O)[CH:8]=1)([O-:3])=[O:2].[CH2:21]([NH2:23])[CH3:22]>C(O)C>[CH2:21]([NH:23][C:10](=[O:12])[CH:9]([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH3:22]

参加物

4

反応物 2

HCID 6341EthylamineHCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate

生成物 1

HCID 15222339N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Ethyl 2-(4-nitro-1H-imidazol-1-yl)octanoate (17 moles, 5.0 g) and ethylamine (20 ml) were stirred in 150 ml ethanol at room temperature for 16 hours. The reaction was added to ice water, extracted with ethyl acetate, washed with water, dried over sodium sulfate and concentrated. The oil crystallized upon standing to yield 3.9 g of N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide. (MS).

後処理

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe oil crystallized

出典と根拠

ORDレコード
ord-fd4c582d41ef494f8ba2e0064e6fd39f
出典データセット
uspto-grants-1996_01
特許番号
US05484780

関連ノート

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