Hydrazine hydrate (1:1) → 8-Amino-5-methoxy-7-methylpyrido[3,4-d]pyridazine-1,4(2H,3H)dione
反応式
[NH2:1][C:2]1[C:3]([CH3:18])=[N:4][C:5]([O:16][CH3:17])=[C:6]([C:12](OC)=[O:13])[C:7]=1[C:8](OC)=[O:9].O.[NH2:20][NH2:21]>CO>[NH2:1][C:2]1[C:7]2[C:8](=[O:9])[NH:21][NH:20][C:12](=[O:13])[C:6]=2[C:5]([O:16][CH3:17])=[N:4][C:3]=1[CH3:18]参加物
4
実験手順
In 8 ml of methanol was dissolved 280 mg of 3-amino-4,5-dimethoxycarbonyl-6-methoxy-2-methylpyridine, and then 0.54 ml (10 eq.) of hydrazine monohydrate was added to the solution. The mixture was refluxed. The resulting crystals were collected by filtration and washed with methanol. The crystals were suspended in water, and the suspension was acidified with hydrochloric acid. The crystals were collected by filtration and washed with water.
後処理
- temperatureThe mixture was refluxed
- filtrationThe resulting crystals were collected by filtration
- washwashed with methanol
- filtrationThe crystals were collected by filtration
- washwashed with water
出典と根拠
- ORDレコード
- ord-f4f305908160453da04621d5040e11e3
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420275
反応ノート
読み込み中…