5,6-Diamino-1,3-diethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,5-dimethyl-4-methoxy)phenyl)ethenyl)-, (E)-

HRID 375296

反応式

HRID 375296 の反応式
[NH2:1][C:2]1[C:3](=[O:14])[N:4]([CH2:12][CH3:13])[C:5](=[O:11])[N:6]([CH2:9][CH3:10])[C:7]=1[NH2:8].[CH3:15][O:16][C:17]1[C:27]([CH3:28])=[CH:26][C:20]([CH:21]=[CH:22][C:23](O)=O)=[C:19]([CH3:29])[CH:18]=1>>[CH2:12]([N:4]1[C:3](=[O:14])[C:2]2[NH:1][C:23](/[CH:22]=[CH:21]/[C:20]3[CH:26]=[C:27]([CH3:28])[C:17]([O:16][CH3:15])=[CH:18][C:19]=3[CH3:29])=[N:8][C:7]=2[N:6]([CH2:9][CH3:10])[C:5]1=[O:11])[CH3:13]

参加物

3

反応物 2

HCID 45721335,6-Diamino-1,3-diethyluracilHCID 51998984-Methoxy-2,5-dimethylcinnamic acid

生成物 1

HCID 64488591H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-(2-(2,5-dimethyl-4-methoxy)phenyl)ethenyl)-, (E)-収率 52.3%

実験手順

Substantially the same procedure as in Example 7 was repeated using 2.5 g (12.6 mmol) of 5,6-diamino-1,3-diethyluracil and 2.9 g (13.9 mmol) of 4-methoxy-2,5-dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from dioxane/water to give 2.43 g (yield 52%) of Compound 74 as white crystals.

後処理

  1. customThen, the resultant crude crystals were recrystallized from dioxane/water

出典と根拠

ORDレコード
ord-88795606de874e8584742da57ead9c5a
出典データセット
uspto-grants-1996_01
特許番号
US05484920

関連ノート

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