5,6-Diamino-1,3-dimethyluracil → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(2-(2,3-dimethyl-4-methoxyphenyl)ethenyl)-, (E)-

HRID 375301

反応式

HRID 375301 の反応式
[NH2:1][C:2]1[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=1[NH2:8].[CH3:13][O:14][C:15]1[CH:25]=[CH:24][C:18]([CH:19]=[CH:20][C:21](O)=O)=[C:17]([CH3:26])[C:16]=1[CH3:27]>>[CH3:13][O:14][C:15]1[CH:25]=[CH:24][C:18](/[CH:19]=[CH:20]/[C:21]2[NH:1][C:2]3[C:3](=[O:12])[N:4]([CH3:11])[C:5](=[O:10])[N:6]([CH3:9])[C:7]=3[N:8]=2)=[C:17]([CH3:26])[C:16]=1[CH3:27]

参加物

3

反応物 2

HCID 795015,6-Diamino-1,3-dimethyluracilHCID 534017704-Methoxy-2,3-dimethylcinnamic acid

生成物 1

HCID 64488651H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-8-(2-(2,3-dimethyl-4-methoxyphenyl)ethenyl)-, (E)-収率 22%

実験手順

Substantially the same procedure as in Example 7 was repeated using 1.74 g (10.2 mmol) of 5,6-diamino-1,3-dimethyluracil and 2.42 g (11.8 mmol) of 4-methoxy-2,3dimethylcinnamic acid. Then, the resultant crude crystals were recrystallized from acetonitrile to give 750 mg (yield 22%) of Compound 84 as a white powder.

後処理

  1. customThen, the resultant crude crystals were recrystallized from acetonitrile

出典と根拠

ORDレコード
ord-b85bc2fbc6164ae689259bd2b7e5fedf
出典データセット
uspto-grants-1996_01
特許番号
US05484920

関連ノート

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