HCID 18992239、化合物 → 3-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

HRID 375617ノート

反応式

HRID 375617 の反応式
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=S)[N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1>O1CCCC1.[Ni]>[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][N:7]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C:8]3=[N:9]2)=[CH:4][CH:3]=1

参加物

4

反応物 1

HCID 18992239HCID 18992239、化合物

生成物 1

HCID 153377963-Methyl-6,7,8,9,10,12-hexahydroazepino[2,1-b]quinazoline

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a mechanically stirred solution of 5 g of 3-methyl-7,8,9,10-tetrahydroazepino[2,1-b]quinazoline-12(6H)-thione in 150 mL of boiling tetrahydrofuran was added in small portions wet Raney nickel (W-2, Davison Chemical, Chattanooga, Tenn.). The progress of the reaction was followed by TLC. When the reaction was complete, the mixture was filtered, solids on the filter were washed thoroughly with tetrahydrofuran and the filtrate was concentrated down. The rest of the workup was identical to that described in method A.

後処理

  1. filtrationthe mixture was filtered
  2. washsolids on the filter were washed thoroughly with tetrahydrofuran
  3. concentrationthe filtrate was concentrated down

出典と根拠

ORDレコード
ord-92e2953887524df6b32e2ef4598bd23f
出典データセット
uspto-grants-1996_01
特許番号
US05486512

反応ノート

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