Phenylmethyl alpha-[[[2-(dimethylamino)ethyl]sulfonyl]methyl]benzenepropanoate → alpha-[[[2-(Dimethylamino) ethyl]sulfonyl]methyl]benzenepropanoic acid

HRID 375834ノート

反応式

HRID 375834 の反応式
[CH3:1][N:2]([CH3:27])[CH2:3][CH2:4][S:5]([CH2:8][CH:9]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]([O:12]CC1C=CC=CC=1)=[O:11])(=[O:7])=[O:6]>C(O)C.[Pd]>[CH3:27][N:2]([CH3:1])[CH2:3][CH2:4][S:5]([CH2:8][CH:9]([CH2:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:10]([OH:12])=[O:11])(=[O:7])=[O:6]

参加物

4

反応物 1

HCID 15296672Phenylmethyl alpha-[[[2-(dimethylamino)ethyl]sulfonyl]methyl]benzenepropanoate

生成物 1

HCID 15780266alpha-[[[2-(Dimethylamino) ethyl]sulfonyl]methyl]benzenepropanoic acid収率 91.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The title compound of Step 12 (150 mg, 0.4 mmol) was debenzylated in ethanol with 5 psi H2 at room temperature for 1.5 hours using 4% Pd/C catalyst. After filtering, the solvent was stripped off to give the title compound as white powder (110 mg, 70%yield). 1H NMR: 300 MHz spectrum consistent with proposed structure. Anal. calcd. for C14H21NO4S: C, 56.16; H, 7.07; N, 4.68. Found: C, 55.88; H, 6.99; N, 4.35.

後処理

  1. filtrationAfter filtering

出典と根拠

ORDレコード
ord-61ae8b9726864c3996cb5592b3fcfce1
出典データセット
uspto-grants-1996_01
特許番号
US05488067

反応ノート

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