Methanol → 2-Phenoxybenzaldoxime

HRID 376043

反応式

HRID 376043 の反応式
[O:1]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO.Cl.[NH2:19][OH:20]>O>[O:1]([C:8]1[CH:15]=[CH:14][CH:13]=[CH:12][C:9]=1[CH:10]=[N:19][OH:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 887MethanolHCID 88060o-PhenoxybenzaldehydeHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 7374792-Phenoxybenzaldoxime収率 74.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To 2-phenoxybenzaldehyde (4.96 g, 0,025 mole) were added anhydrous methanol (50 ml) and hydroxylamine hydrochloride (2.08 g, 0.03 mole), and the mixture was stirred at 60° C. for 3 hours. After completion of the reaction, water (200 ml) was added to the reaction mixture, which was extracted with methylene chloride and dried over magnesium sulfate. The crude product obtained by concentration under reduced pressure was purified by silica gel chromatography (ethyl acetate/n-hexane) to obtain 2-phenoxybenzaldoxime (3.95 g, yield: 74.1%) as a colorless oil.

後処理

  1. additionwas added to the reaction mixture, which
  2. extractionwas extracted with methylene chloride
  3. dry with materialdried over magnesium sulfate
  4. customThe crude product obtained by concentration under reduced pressure
  5. customwas purified by silica gel chromatography (ethyl acetate/n-hexane)

出典と根拠

ORDレコード
ord-c47a8e14fc5e44968bc82ea373aac1e0
出典データセット
uspto-grants-1996_01
特許番号
US05488159

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