Formaldehyde → 4-Benzoyloxy-2-methylenebutanal
反応式
[C:1]([O:9][CH2:10][CH2:11][CH2:12][CH:13]=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[CH3:16][NH2+]C.C=O>>[C:1]([O:9][CH2:10][CH2:11][C:12](=[CH2:16])[CH:13]=[O:14])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
10 g (52 mmol) of 4-benzoyloxybutanal, 4.78 g (58.6 mmol) of dimethylammonium chloride and 4.6 ml (60.8 mmol) of formaldehyde solution (37%) are refluxed for one hour with stirring (bath temperature ~110° C.). The mixture is allowed to cool and is extracted three times with ether; the organic phases are combined, washed with saturated sodium chloride solution, dried over MgSO4, filtered and concentrated by evaporation. 4-benzoyloxy-2-methylenebutanal is obtained in the form of a yellowish oil which can be reacted without further purification.
後処理
- temperatureto cool
- extractionis extracted three times with ether
- washwashed with saturated sodium chloride solution
- dry with materialdried over MgSO4
- filtrationfiltered
- concentrationconcentrated by evaporation
出典と根拠
- ORDレコード
- ord-2f4efddb87e4413281bea570a1c82231
- 出典データセット
- uspto-grants-1996_01
- 特許番号
- US05488140
反応ノート
読み込み中…