Formaldehyde → 6-Acetoxy-2-methylene-hexanal

HRID 376149

反応式

HRID 376149 の反応式
[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH:10]=[O:11])(=[O:3])[CH3:2].[Cl-].[CH3:13][NH2+]C.C=O>>[C:1]([O:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[CH2:13])[CH:10]=[O:11])(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 712FormaldehydeHCID 69174896-Oxohexyl acetateHCID 12954980Dimethylazanium;chloride

生成物 1

HCID 189915606-Acetoxy-2-methylene-hexanal

実験手順

16 g (101.1 mmol) of 6-acetoxyhexanal, 9.2 g (113 mmol) of dimethylammonium chloride and 9.2 ml (118.3 mmol) of a 37% solution of formaldehyde are stirred for 1 hour at a bath temperature of 110° C. The mixture is allowed to cool and extracted three times with CH2Cl2. The combined organic phases are dried over Na2SO4, filtered, and concentrated by evaporation giving 6-acetoxy-2-methylene-hexanal as a slightly yellowish oil which is further reacted without purification.

後処理

  1. temperatureto cool
  2. extractionextracted three times with CH2Cl2
  3. dry with materialThe combined organic phases are dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-201f78481e0b4b018808e9cfba22d1be
出典データセット
uspto-grants-1996_01
特許番号
US05488140

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