Hydrochloric Acid → (4-Methoxyphenyl)glycolonitrile
反応式
[C-]#N.[Na+].[CH3:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH:12]=[O:13])=[CH:10][CH:11]=1.[CH2:14]([N:16](CC)CC)C.Cl>C(O)C>[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([OH:13])[C:14]#[N:16])=[CH:8][CH:7]=1参加物
6
実験手順
To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.
後処理
- aliquotIn situ sampling of the reaction mixture
- customthe reaction
- customto quench
- customthe reaction
- filtrationtHE solution is filtered
- customused in the next step without further purification
- customYield
出典と根拠
- ORDレコード
- ord-d70c30dd3e6440eaa4466dd6b2a1c444
- 出典データセット
- uspto-grants-1995_05
- 特許番号
- US05420349
反応ノート
読み込み中…