Hydrochloric Acid → (4-Methoxyphenyl)glycolonitrile

HRID 37625

反応式

HRID 37625 の反応式
[C-]#N.[Na+].[CH3:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([CH:12]=[O:13])=[CH:10][CH:11]=1.[CH2:14]([N:16](CC)CC)C.Cl>C(O)C>[CH3:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH:12]([OH:13])[C:14]#[N:16])=[CH:8][CH:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric Acid2 回HCID 8471TriethylamineHCID 8929Sodium CyanideHCID 312444-Methoxybenzaldehyde

生成物 1

HCID 36571(4-Methoxyphenyl)glycolonitrile

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To 49 g (1 mole) of sodium cyanide and 136 g (1 mole) anisaldehyde in ethyl alcohol 800 ml), containing triethylamine (5 mol %, 5.1 g) is added HCl gas (1 mol, 36.5 g) over 30 minutes at 5°-10° C. The resulting slurry is stirred at that temperature for 6 hours. In situ sampling of the reaction mixture shows the reaction to be complete. Additional HCl (0.2 moles) is added to quench the reaction. tHE solution is filtered and used in the next step without further purification. Yield, ca. 80%.

後処理

  1. aliquotIn situ sampling of the reaction mixture
  2. customthe reaction
  3. customto quench
  4. customthe reaction
  5. filtrationtHE solution is filtered
  6. customused in the next step without further purification
  7. customYield

出典と根拠

ORDレコード
ord-d70c30dd3e6440eaa4466dd6b2a1c444
出典データセット
uspto-grants-1995_05
特許番号
US05420349

関連ノート

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