(5-Methyl-6-methylaminopyridin-2-yl)methanol → 5-Methyl-6-methylamino-2-pyridinecarboxaldehyde
反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:10][OH:11])=[N:6][C:7]=1[NH:8][CH3:9]>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH:10]=[O:11])=[N:6][C:7]=1[NH:8][CH3:9]参加物
4
実験手順
A suspension of 0.33 g of (5-methyl-6-methylaminopyridin-2-yl)methanol (2.17 mmol) and 1.6 g of manganese dioxide (18.4 mmol) in 12 ml of chloroform is heated under reflux for 1 hour. The insoluble matter is removed by filtration on celite and then the solvent evaporated under vacuum. The title product is purified by chromatography on a silica column (eluent: chloroform). 0.25 g of a yellow solid is recovered.
後処理
- temperatureis heated
- temperatureunder reflux for 1 hour
- customThe insoluble matter is removed by filtration on celite
- customthe solvent evaporated under vacuum
- customThe title product is purified by chromatography on a silica column (eluent: chloroform)
- custom0.25 g of a yellow solid is recovered
出典と根拠
- ORDレコード
- ord-1478e1772b3e4ab19c1c736cf92f7273
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06020345
反応ノート
読み込み中…