Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine
反応式
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1参加物
4
実験手順
To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH (10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compound as a brown oil(240 mg, solidified on standing).
後処理
- customvolatile solvent was removed in vacuo
- extractionextracted with CHCl3(3×)
- washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
- customevaporated
出典と根拠
- ORDレコード
- ord-f79ec0dd0b9e40458cd8ee59575cc942
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06020343
反応ノート
読み込み中…