Tetrahydrofuran → 5'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

HRID 376448ノート

反応式

HRID 376448 の反応式
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11](SC)=[CH:10][CH:9]=2)[CH:7]=1.O[O:19][S:20]([O-:22])=O.[K+].[CH2:24]1COCC1>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:16]=[O:17])=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:20]([CH3:24])(=[O:22])=[O:19])=[CH:10][CH:9]=2)[CH:7]=1

参加物

6

反応物 3

HCID 8028TetrahydrofuranHCID 193619465'-Fluoro-2'-Formyl-4-MethylthiobiphenylHCID 23707502Potassium hydroxy sulfite

生成物 1

HCID 193619415'-Fluoro-2'-Formyl-4-Methylsulfonyl biphenyl

試薬・触媒・溶媒 2

HCID 94433Tetrabutylammonium hydrogen sulfate触媒HCID 962Water溶媒2 回

実験手順

5'-Fluoro-2'-formyl-4-methylthiobiphenyl (10 mmol) (Example 1E) in THF (20 ml) is charged dropwise with oxone® (6 mmol) and tetrabutylammonium hydrogensulfate (1 mmol) in water (15 ml). The mixture is stirred at room temperature for 1 hour. The suspension is poured into water (300 ml), the precipitate is filtered off, is washed with water and is dried in vacuo to give the title product.

後処理

  1. filtrationthe precipitate is filtered off
  2. washis washed with water
  3. customis dried in vacuo

出典と根拠

ORDレコード
ord-382c66dc8b9d4744a64ecbb415b1b451
出典データセット
uspto-grants-2000_02
特許番号
US06020379

反応ノート

読み込み中…