Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylate

HRID 376460ノート

反応式

HRID 376460 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]=O)[N:4]=[N:3]1.[CH3:9][O:10][C:11]([CH:13]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:12]>ClCCl>[CH3:9][O:10][C:11](=[O:12])/[CH:13]=[CH:7]/[C:5]1[N:4]=[N:3][N:2]([CH3:1])[CH:6]=1

参加物

4

反応物 2

HCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 143134381-Methyl-1H-1,2,3-triazole-4-carboxaldehyde

生成物 1

HCID 21202730Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylate収率 212.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

1-Methyl-1,2,3-triazol-4-carboxaldehyde (1 g, 9 mmol) was added to a solution of methoxycarbonylmethylene triphenylphosphorane (4.5 g, 13.5 mmol) in dichloromethane (50 ml) and stirred at room temperature for 3.5 hours. The solvent was removed and the residue purified by silica gel chromatography to afford the title compound, (3.2 g).

後処理

  1. customThe solvent was removed
  2. customthe residue purified by silica gel chromatography

出典と根拠

ORDレコード
ord-306f5d0ea46a40ce95e15948c0726ac3
出典データセット
uspto-grants-2000_02
特許番号
US06020368

反応ノート

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