Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride

HRID 376462ノート

反応式

HRID 376462 の反応式
[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5](O)=[O:6])[CH2:3]1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C=O)C>[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5]([Cl:14])=[O:6])[CH2:3]1

参加物

5

反応物 2

HCID 65578Oxalyl chlorideHCID 27369371-methylpiperidine-3-carboxylic Acid

生成物 1

HCID 200260181-Methylpiperidine-3-carbonyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.

後処理

  1. customThe solvent was then evaporated

出典と根拠

ORDレコード
ord-38471196f515436496682fd4efba0d12
出典データセット
uspto-grants-2000_02
特許番号
US06020368

反応ノート

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