Chlorotrimethylsilane → HCID 18630201、化合物

反応式

[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[CH3:2].[CH3:12][Si:13](Cl)([CH3:15])[CH3:14]>>[CH2:1]([NH:3][C:4](=[O:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[Si:13]([CH3:15])([CH3:14])[CH3:12])[CH3:2]

参加物

反応物 2

HCID 6397Chlorotrimethylsilane

HCID 11959N-Ethylbenzamide

生成物 1

HCID 18630201HCID 18630201、化合物収率 68.3%

実験手順

N-Ethylbenzamide (74.5 g, 500 mmol) and TMSCl (135.8 g, 1.25 mol) were combined according to General Method C and purified by HPLC with 1:4 ethyl acetate/hexanes to afford 75.59 g of the title compound, as a white solid, a 68% yield. m.p. 64.0°-66.0° C.

後処理

custompurified by HPLC with 1:4 ethyl acetate/hexanes

出典と根拠

ORDレコード: ord-da0f6698618e46f7b902c0a6489825fb
出典データセット: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: USRE036562

反応ノート

読み込み中…