Sodium Hydroxide → 4-(2,3-Dimethoxyphenyl)4-piperidinylmethanone
反応式
FC(F)(F)C(O)=O.[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.[OH-].[Na+]>O>[CH3:8][O:9][C:10]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[C:18]1([CH:24]=[O:25])[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1参加物
4
実験手順
The resulting 4-(2,3-dimethoxyphenyl)-4-piperidinyl-methanone trifluoroacetate was dissolved in water, treated with NaOH (10% aqueous) until basic, and extracted three times with dichloromethane. The combined organic layers were washed with brine, dried (MgSO4), filtered, and evaporated to afford 4-(2,3-dimethoxyphenyl)-4-piperidinylmethanone as an oil.
後処理
- extractionextracted three times with dichloromethane
- washThe combined organic layers were washed with brine
- dry with materialdried (MgSO4)
- filtrationfiltered
- customevaporated
出典と根拠
- ORDレコード
- ord-a36aab6ea37745ee89e233082b25e165
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06022877
反応ノート
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