Guanidine → N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride

反応式

[Cl:1][C:2]1C=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][C:3]=1CNC.C1N=[CH:18][N:17]([C:20]([N:22]2[CH:26]=[N:25][CH:24]=[CH:23]2)=[O:21])C=1.[NH2:27]C(N)=N>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:7][C:8]([C:11]([F:12])([F:14])[F:13])=[CH:9][C:24]=1[CH2:23][N:22]([C:20]([NH:17][CH3:18])=[O:21])[C:26]([NH2:25])=[NH:27]

参加物

反応物 3

HCID 3520Guanidine

HCID 682631,1'-Carbonyldiimidazole

HCID 11951932HCID 11951932、化合物

生成物 1

HCID 19360574N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride収率 77.7%

実験手順

1.0 g of N-(2-chloro-5-trifluoromethylbenzyl)-N-methylamine was reacted with 0.75 g of CDI and 1.1 g of guanidine analogously to Example 23. 0.6 g of N-(2-chloro-5-trifluoromethylbenzyl)-N-methylaminocarbonylguanidine hydrochloride is obtained;

出典と根拠

ORDレコード: ord-758a2f1466fe457496b04e0f8a640eab
出典データセット: uspto-grants-2000_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06022899

反応ノート

読み込み中…

参加物