Formaldehyde → 3-(3-Bromo-4-chlorophenyl)thiazolidin-4-one

HRID 377021ノート

反応式

HRID 377021 の反応式
[C:1]([OH:5])(=O)[CH2:2][SH:3].[CH2:6]=O.[Br:8][C:9]1[CH:10]=[C:11]([CH:13]=[CH:14][C:15]=1[Cl:16])[NH2:12]>C1(C)C=CC=CC=1>[Br:8][C:9]1[CH:10]=[C:11]([N:12]2[C:1](=[O:5])[CH2:2][S:3][CH2:6]2)[CH:13]=[CH:14][C:15]=1[Cl:16]

参加物

5

反応物 3

HCID 712FormaldehydeHCID 1133Thioglycolic AcidHCID 128437223-Bromo-4-chloroaniline

生成物 1

HCID 193607783-(3-Bromo-4-chlorophenyl)thiazolidin-4-one

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

Thioglycolic acid (8.65 g) and 37% aqueous formaldehyde (4.6 ml) was added to a stirred solution of 3-bromo-4-chloroaniline (9.73 g) in toluene (50 ml). The mixture was heated to reflux and the water collected in a Dean and Stark apparatus. After 3 hours the mixture was cooled, diluted with toluene then washed with aqueous sodium hydroxide and water. The organic layer was dried (MgSO4) and concentrated to give the subtitle compound as a solid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureto reflux
  3. customthe water collected in a Dean and Stark apparatus
  4. temperatureAfter 3 hours the mixture was cooled
  5. additiondiluted with toluene
  6. washthen washed with aqueous sodium hydroxide and water
  7. dry with materialThe organic layer was dried (MgSO4)
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-55f5dd449ef5494aac677a1f07786f7f
出典データセット
uspto-grants-2000_02
特許番号
US06022976

反応ノート

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