6-Benzyloxy-1,1-dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole → HCID 19935696、化合物

HRID 37704ノート

反応式

HRID 37704 の反応式
[CH3:1][C:2]1([CH3:23])[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][O:3]1)=[CH:13][C:12]([O:15]CC1C=CC=CC=1)=[CH:11][CH:10]=3>[Pd].C(O)C>[CH3:1][C:2]1([CH3:23])[C:7]2[NH:8][C:9]3[C:14]([C:6]=2[CH2:5][CH2:4][O:3]1)=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=3

参加物

4

反応物 1

HCID 199357106-Benzyloxy-1,1-dimethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole

生成物 1

HCID 19935696HCID 19935696、化合物収率 115.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture consisting of 10% Pd/c on charcoal (0.7 g), ethanol (150 mL) and 1,3,4,9-tetrahydro-1,1-dimethyl-6-(phenylmethoxy)pyrano[3,4-b]indole (4.2 g, 0.014 mol) of Step A, is hydrogenated at 30 psi for 18 hours. The reaction mixture is filtered and concentrated to give 3.5 g product which is used in the next reaction without further purification.

後処理

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-dc53ca22d1b544e6a12bcff46bc4b310
出典データセット
uspto-grants-1995_05
特許番号
US05420289

反応ノート

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