Hydrochloric Acid → 4-Amino-2-fluoro-3-methylbenzoic acid
反応式
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([F:13])[C:3]=1[CH3:14].[OH-].[Na+].Cl>C(O)C>[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:13])[C:3]=1[CH3:14]参加物
5
実験手順
In 7 ml of ethanol was suspended 0.70 g of ethyl 4-amino-2-fluoro-3-methylbenzoate, followed by adding thereto 7 ml of lN sodium hydroxide, and the resulting mixture was stirred at 40° C. for 4 hours. To the reaction mixture was added 1.2 ml of 6N hydrochloric acid, followed by extraction with 50 ml of ethyl acetate. The extract solution was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent, to obtain 0.59 g of 4-amino-2-fluoro-3-methylbenzoic acid as colorless crystals.
後処理
- additionby adding
- extractionfollowed by extraction with 50 ml of ethyl acetate
- washThe extract solution was washed with a saturated aqueous sodium chloride solution
- dry with materialdried over anhydrous magnesium sulfate
- distillationdistilled under reduced pressure
- customto remove the solvent
出典と根拠
- ORDレコード
- ord-eb8017b3b8a348f08efb059870b50d3e
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06025370
反応ノート
読み込み中…