Br.[Br:2][C:3]1[CH:4]=C2[C:9](=[CH:10][CH:11]=1)CNC2.C([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])C.ClC([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O.Cl.[OH2:31]>C(Cl)Cl>[CH2:23]([O:22][N:14]1[CH2:15][C:16]2[C:9](=[CH:10][CH:11]=[C:3]([Br:2])[CH:4]=2)[C:17]1=[C:18]=[O:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1In 25 ml of 47% hydrobromic acid was suspended 5.0 g of 5-bromo-2-(p-toluenesulfonyl)isoindoline, followed by adding thereto 4.0 g of phenol and 15 ml of propionic acid, and the resulting mixture was heated under reflux for 4 hours. The reaction mixture was concentrated under reduced pressure, after which ethanol was added to the resulting residue and the crystals were collected by filtration to obtain 3.5 g of 5-bromoisoindoline hydrobromide. The hydrobromide obtained was suspended in 50 ml of methylene chloride, followed by adding thereto 2.8 g of triethylamine. Then, 2.4 g of benzyl chloroformate was added dropwise thereto and the resulting mixture was stirred at room temperature for 1 hour. The reaction mixture was added to 50 ml of water and the pH was adjusted to 1 with 6N hydrochloric acid, after which the organic layer was separated. The organic layer obtained was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then distilled under reduced pressure to remove the solvent. n-Hexane was added to the resulting residue and the crystals were collected by filtration to obtain 3.8 g of colorless 2-benzyloxy-carbonyl-5-bromoisoindoline.
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