化工社化工社 化学情報印刷レポート · 研究参考用
(+-)-Methionine → 3'-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (+-)-Methionine | HCID 876 | — |
| 反応物 | 3'-Methoxy-biphenyl-3-carboxylic acid | HCID 2759550 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Methanesulfonic Acid | HCID 6395 | — |
| 生成物 | 3'-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid | HCID 2759301 | 93.3% |
反応手順
A suspension of 3'-methoxy-3-biphenylcarboxylic acid (4.1 g) and DL-methionine (26.7 g) in methanesulfonic acid (116 ml) was stirred at room temperature for 22 hours, diluted with water, and extracted three times with diethyl ether. The extracts were combined, washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was crystallized from n-hexane to afford 3'-hydroxy-3-biphenylcarboxylic acid (3.59 g) as a colorless powder.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06025375 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-912e2197e69c4bb7a28b8e9c6f6a6ac3 |
| 出典メモ | uspto-grants-2000_02 |