(+-)-Methionine → 3'-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid

HRID 377311ノート

反応式

HRID 377311 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([OH:17])=[O:16])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1.NC(C(O)=O)CCSC>CS(O)(=O)=O.O>[OH:2][C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([OH:17])=[O:16])[CH:10]=2)[CH:6]=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 876(+-)-MethionineHCID 27595503'-Methoxy-biphenyl-3-carboxylic acid

生成物 1

HCID 27593013'-Hydroxy-[1,1'-biphenyl]-3-carboxylic acid収率 93.3%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6395Methanesulfonic Acid溶媒

実験手順

A suspension of 3'-methoxy-3-biphenylcarboxylic acid (4.1 g) and DL-methionine (26.7 g) in methanesulfonic acid (116 ml) was stirred at room temperature for 22 hours, diluted with water, and extracted three times with diethyl ether. The extracts were combined, washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was crystallized from n-hexane to afford 3'-hydroxy-3-biphenylcarboxylic acid (3.59 g) as a colorless powder.

後処理

  1. extractionextracted three times with diethyl ether
  2. washwashed with brine
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo
  5. customThe residue was crystallized from n-hexane

出典と根拠

ORDレコード
ord-912e2197e69c4bb7a28b8e9c6f6a6ac3
出典データセット
uspto-grants-2000_02
特許番号
US06025375

反応ノート

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