CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
反応式
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1参加物
4
実験手順
To p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mole) in 3.6 liters ethanol is added 11.0 g of 5% Pd/C and the mixture is reduced at room temperature under a hydrogen pressure of 40 p.s.i.; uptake is 31-32 lbs. (97% of theoretical). After the catalyst is filtered, the filtrate is concentrated in vacuo to give the product p-fluoro-α-methylhydrocinnamic acid that is used without weighing in next step.
後処理
- customis reduced at room temperature under a hydrogen
- filtrationAfter the catalyst is filtered
- concentrationthe filtrate is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-7e550f3fcd4947b99feec74532aa5a23
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06025394
反応ノート
読み込み中…