Water → 7-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

HRID 3775

反応式

HRID 3775 の反応式
[OH-].[K+].O.[OH:4][C:5]1[C:13]2[O:12][C:11]([CH3:15])([CH3:14])[CH:10]([N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1.[Br:22][CH2:23][CH2:24][CH2:25]Br>[Cl-].C([N+](CCCC)(CCCC)CCCC)CCC.C(OCC)C>[Br:22][CH2:23][CH2:24][CH2:25][O:4][C:5]1[C:13]2[O:12][C:11]([CH3:14])([CH3:15])[CH:10]([N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)[C:9]=2[CH:8]=[CH:7][CH:6]=1

参加物

7

反応物 4

HCID 962WaterHCID 80011,3-DibromopropaneHCID 14797Potassium HydroxideHCID 141266507-Hydroxy-3-piperidino-2,2-dimethylbenzofuran

生成物 1

HCID 141266517-(3-Bromopropoxy)-3-piperidino-2,2-dimethylbenzofuran

試薬・触媒・溶媒 2

HCID 70681Tetrabutylammonium Chloride触媒HCID 3283Diethyl Ether溶媒2 回

実験手順

Potassium hydroxide (1.47 g), tetrabutyl ammonium chloride (0.77 g) and H2O (1 ml) are added to a solution of the product obtained in Step 6. (6.6 g) in 1,3-dibromopropane (27 ml). The reaction mixture is stirred for 20 hours and diluted with diethyl ether and washed with 5% aq. HCl. The acidic solution is washed with ether and basified, affording an oil which is taken up in ether, washed with sat'd NaCl, dried, filtered and evaporated in vacuo affording the desired product as an oil.

後処理

  1. washwashed with 5% aq. HCl
  2. washThe acidic solution is washed with ether
  3. custombasified, affording an oil which
  4. washwashed with sat'd NaCl
  5. customdried
  6. filtrationfiltered
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-f0acfd39ea7a462683b5b3c43269d05e
出典データセット
uspto-grants-1988_02
特許番号
US04722925

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