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Cyclohexene → 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexene | HCID 8079 | — |
| 反応物 | 4,6-Dichloro-5-nitropyrimidine | HCID 20312 | — |
| 反応物 | 2-Ethylimidazole | HCID 66130 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | 1-Methyl-4-(methylamino)piperidine | HCID 566323 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 9-Ethyl-4-[(1-methylpiperidin-4-yl)methylamino]imidazo[5,1-h]pteridin-6(5H)-one | HCID 70270934 | — |
反応手順
Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with 1-methyl-4-(methylamino)piperidine followed by reaction with 2-ethylimidazole, reduction with palladium on carbon and cyclohexene in refluxing ethanol, and cyclization with carbonyidiimidazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06025489 |
| 出典データセット | uspto-grants-2000_02 |
| ORD ID | ord-3212f7b590b4430483b6c6024c3e6bfd |
| 出典メモ | uspto-grants-2000_02 |