Toluene → HCID 53778754、化合物
反応式
[C:1]1([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:12])=O.[C:14]1([CH3:20])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[Cl:12][CH:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:3]1[CH:2]=[C:1]([CH2:7][C:8]#[N:9])[CH:6]=[CH:5][CH:4]=1参加物
4
実験手順
9 g of 3-hydroxyphenylmethyl)phenylacetonitrile are dissolved in 150 ml of toluene and treated with stirring with 5.8 ml (80 mmol) of thionyl chloride. The reaction mixture is heated to reflux temperature and stirred for one hour. In the course of this, approximately 50 ml of toluene are removed in a water separator. The solvent is removed and 3-(chlorophenyl-methyl)phenylacetonitrile is obtained.
後処理
- additiontreated
- temperatureThe reaction mixture is heated
- temperatureto reflux temperature
- customIn the course of this, approximately 50 ml of toluene are removed in a water separator
- customThe solvent is removed
出典と根拠
- ORDレコード
- ord-715a8484b6f945f58156c48cdbcf18eb
- 出典データセット
- uspto-grants-2000_02
- 特許番号
- US06028080
反応ノート
読み込み中…