Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 377613

反応式

HRID 377613 の反応式
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1)[NH2:3]

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 52825666-Chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Hydrazine hydrate (6.5 ml) was added to a solution of 6-chloro-3-methyl-1-(2-methylpropyl)pyrimidine-2,4[1H,3H]-dione (10.0 g) in ethanol (40 ml). The mixture was heated at reflux for 5 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was recrystallised from ethanol to give the subtitle compound (8.8 g).

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 5 hours
  3. customevaporated under reduced pressure
  4. customThe residue was recrystallised from ethanol

出典と根拠

ORDレコード
ord-0babe5e48b794874b958f26057a9078b
出典データセット
uspto-grants-2000_02
特許番号
US06028074

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