CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid

HRID 377740

反応式

HRID 377740 の反応式
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

参加物

4

反応物 1

HCID 367964CID 367964

生成物 1

HCID 154877913-(4-Fluorophenyl)-2-methylpropanoic acid

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.

後処理

  1. customis hydrogenated at room temperature at 40 p.s.i
  2. filtrationWhen the hydrogen uptake ceases, the catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-a801ed2c651849f5bf6530bfe49a45db
出典データセット
uspto-grants-2000_02
特許番号
US06028116

関連ノート

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