Methanol → 1-Azabicyclo[3.2.2]nonan-4-one

HRID 37783

反応式

HRID 37783 の反応式
[CH3:1][Si](C=[N+]=[N-])(C)C.CCCCCC.[N:14]12[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]1)[C:16](=[O:22])[CH2:15]2.CO>O1CCCC1>[N:14]12[CH2:21][CH2:20][CH:17]([CH2:18][CH2:19]1)[C:16](=[O:22])[CH2:15][CH2:1]2

参加物

5

反応物 3

HCID 887MethanolHCID 195073-QuinuclidinoneHCID 86587183Trimethylsilyldiazomethane hexane

生成物 1

HCID 64203071-Azabicyclo[3.2.2]nonan-4-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

An ice-cooled solution (5° C.) of (trimethylsilyl)diazomethane/hexane (2 N, 30 mL, 60 mmol; Aldrich) under nitrogen was treated dropwise with a solution of quinuclidin-3-one (7500 mg, 60 mmol) in dry tetrahydrofuran (40 mL). Methanol (20 mL) was added, and the yellow solution was warmed to room temperature, stirred for 24 hours, and quenched to colorless by addition of acetic acid. After a few minutes, saturated aqueous sodium carbonate (15 mL) was added. The organic layer was separated, and the aqueous solution was extracted with methylene chloride (3×50 mL). The combined organic layer and extracts were dried over magnesium sulfate, and concentrated in vacuo to give the titled compound. The material was used directly for next step without further purification.

後処理

  1. customquenched
  2. additionto colorless by addition of acetic acid
  3. waitAfter a few minutes
  4. additionsaturated aqueous sodium carbonate (15 mL) was added
  5. customThe organic layer was separated
  6. extractionthe aqueous solution was extracted with methylene chloride (3×50 mL)
  7. dry with materialThe combined organic layer and extracts were dried over magnesium sulfate
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-788482f2c86d4fcf85ad7c5a22fe736c
出典データセット
uspto-grants-2013_09
特許番号
US08524703B2

関連ノート

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